转动物头饰和角的快速再生的遗传基础
Yu Wang1, Chenzhou Zhang2, Nini Wang1
1Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.
Science (New York, N.Y.)
|June 22, 2019
概括
食动物是独一无二的哺乳动物, 这些结构来自神经干细胞的共同起源,与癌症相关的基因相关的角质再生.
科学领域:
- 进化生物学
- 基因组学
- 发育生物学
背景情况:
- 食动物是唯一一个有骨头的哺乳动物群体 (角和角).
- 佩科兰的血统呈现出融合的进化,有些血统缺乏头饰.
- 了解头盔进化和再生的遗传基础至关重要.
研究的目的:
- 研究牛角和鹿角的进化起源.
- 比较头盔发育和再生的遗传基础.
- 探索瘤遗传和瘤抑制途径在的再生中的作用.
主要方法:
- 来自牛和鹿类的221个样本的转录组测序.
- 两种没有头盔的鱼血统的基因组测序.
- 基因组和转录组分析的比较.
主要成果:
- 牛角和鹿角具有类似的基因表达特征和来自神经干细胞的细胞起源.
- Antler再生利用瘤遗传途径,而瘤抑制基因正在鹿中进行选择.
- 在反动物中,头饰的融合进化涉及共同的遗传机制.
结论:
- 食动物的头饰是从从神经干细胞中获得的共同细胞基础进化而来的.
- 子再生突出了器官再生和瘤发生途径之间的相互作用.
- 这项研究提供了哺乳动物特征和复杂生物过程的进化见解.
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