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  3. 在心血管疾病的初级预防中,阿司匹林的上升和下降
  1. 首页
  3. 在心血管疾病的初级预防中,阿司匹林的上升和下降

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在心血管疾病的初级预防中,阿司匹林的上升和下降

Inbar Raber1, Cian P McCarthy2, Muthiah Vaduganathan3

  • 1Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Lancet (London, England)
|June 22, 2019

在PubMed 上查看摘要

概括
此摘要是机器生成的。

阿司匹林广泛用于二次心血管预防. 然而,最近的试验表明阿司匹林在初级预防中几乎没有益处,

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科学领域:

  • 心脏病学
  • 药理学
  • 预防医学

背景情况:

  • 阿司匹林是二次预防心血管疾病的常用药物.
  • 它在初级预防中的作用仍然存在争议,历史试验显示出混合的结果.
  • 指导方针建议阿司匹林仅用于高危人群的初级预防.

研究的目的:

  • 重新评估阿司匹林在主要心血管疾病预防中的作用.
  • 将历史和近期临床试验的发现置于背景中.

主要方法:

  • 历史和当代随机临床试验的叙述性审查.
  • 在初级预防中分析阿司匹林的风险益处概况.

主要成果:

  • 早期的试验表明阿司匹林可以减少心肌梗塞和中风,但会增加出血风险.
  • 最近的2018年试验表明阿司匹林在初级预防中几乎没有益处和潜在的净危害.

结论:

  • 阿司匹林对预防心血管疾病的益处值得怀疑.
  • 最近的证据表明,重新评估阿司匹林在初级预防中的使用是有必要的.