格利亚积累证据表明行动是徒劳的,并抑制不成功的行为
Yu Mu1, Davis V Bennett2, Mikail Rubinov3
1Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Cell
|June 25, 2019
概括
当行为失败时,动物会学会停止尝试. 大脑中的noradrenergic神经元和辐射星细胞跟踪这些失败,促使人们转向被动行为以节省能量.
科学领域:
- 神经科学是一个神经科学.
- 动物行为 动物行为
- 计算神经科学是一种神经科学.
背景情况:
- 动物经常在反复失败后停止行为,被动状态可能有助于节能或战略重组.
- 在行为失败的检测和随后的状态切换的基础上的神经机制在很大程度上仍然没有表征.
研究的目的:
- 为了研究中介神经回路的行为响应运动徒劳的斑马鱼幼虫.
- 识别大脑区域和细胞类型,参与检测失败的行为和启动行为状态的变化.
主要方法:
- 幼虫斑马鱼被置于一个虚拟现实环境中,游泳尝试未能引起预期的视觉反.
- 整个大脑成像被用来监测神经活动在运动徒劳的时期.
- 细胞操纵包括切除和光遗传/化学遗传激活被用来探测神经元功能.
主要成果:
- 幼虫斑马鱼在经历了运动徒劳后表现出被动行为,其持续时间与失败尝试的时间相当.
- 诺拉基神经元对失败的游泳尝试做出了特别的反应,而放射性星球细胞则显示出随着失败的增加而积累的活动.
- 诺拉地能神经元的激活导致脑干放射性星体细胞的激活,这随后抑制了游泳行为.
结论:
- 脑干辐射星细胞整合了行动无效的证据,在行为状态过渡中发挥了关键作用.
- 一个涉及noradrenergic神经元和辐射星细胞的电路介绍了在重复失败后从主动转向被动行为的转换.
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