早期肺状癌发生前的免疫逃避
Céline Mascaux1,2,3,4,5,6, Mihaela Angelova7,8,9,10,11, Angela Vasaturo7,8,9,10
1Department of Intensive Care and Thoracic Oncology, Jules Bordet Institute, Centre des Tumeurs de l'Université Libre de Bruxelles (ULB), ULB, Brussels, Belgium. celine.mascaux@chru-strasbourg.fr.
Nature
|June 28, 2019
概括
在肺癌入侵之前, 研究人员在侵袭前的阶段确定了关键的免疫生物标志物,为高危人群提出了新的早期检测和免疫治疗策略.
科学领域:
- 癌症学
- 免疫学
- 分子生物学
背景情况:
- 癌症的早期发现和治疗对于患者的结果至关重要.
- 了解致癌症需要研究癌前病变和瘤免疫微观环境.
- 适应性免疫反应在癌症早期最强.
研究的目的:
- 在肺癌发生之前研究免疫激活和逃生机制.
- 确定肺癌前期的免疫生物标志物.
- 了解前入侵细胞和免疫反应的共同进化.
主要方法:
- 基因表达分析和多光谱成像.
- 分析了肺状细胞癌发育的9个形态阶段的122个活检.
- 对癌症和免疫路径的进化轨迹的检查.
主要成果:
- 确定了不同的阶段:扩散/DNA修复的线性增加,低度病变中的过渡性免疫感应,高度病变中的免疫激活/脱离,以及侵袭性癌症中的上皮-介质细胞过渡.
- 在瘤入侵之前出现了免疫激活和逃逸.
- 发现与侵袭性肺癌发生相关的特定免疫生物标志物.
结论:
- 肺癌发生涉及前入侵细胞和免疫系统的动态共同进化.
- 这些发现支持早期肺癌检测免疫生物标志物的开发.
- 在高风险人群中建议基于免疫治疗的化学预防.
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