通过大脑干GABA神经元调节能量消耗
Marc Schneeberger1, Luca Parolari1, Tania Das Banerjee2
1Laboratory of Molecular Genetics, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA.
Cell
|July 2, 2019
概括
脊髓中的神经元 (DRN) 调节体温和能量消耗. 这些GABAergic (表达Vgat) 神经元的激活通过直接和间接途径影响热生成和运动.
科学领域:
- 神经科学
- 生理学
- 温度调节
背景情况:
- 控制核心体温对于生存至关重要.
- 神经元感知温度,启动行为和生理反应,
研究的目的:
- 研究背脊神经核 (DRN) 中特定的GABAergic神经元在调节能量消耗和温度调节中的作用.
- 确定这些DRN神经元的投射目标和调节途径.
主要方法:
- 使用光遗传学来刺激和记录背侧DRN中的Vgat表达神经元.
- 追溯到神经突出 拉菲 (RPa),下丘脑和扩展的杏仁体.
- 评估神经元刺激对热生成和运动的影响.
主要成果:
- 脊髓Vgat表达神经元 (DRNVgat) 被热激活
- DRNVgat神经元双向调节能量消耗,影响热生成和运动.
- 这些神经元投射到RPa,下丘脑和扩展的杏仁体,通过直接和间接途径调节温度.
结论:
- 在控制能量消耗和维持体温方面, DRNVgat神经元起着至关重要的作用.
- 这两种向下投射到RPa和向上投射到下丘脑/桃体都有助于温度调节.
相关概念视频
Brainstem
6.0K
The brainstem, located inferior to the brain and superior to the spinal cord, serves as a bridge between the cerebrum and the spinal cord. It plays a vital role in relaying information and controlling critical life functions. It comprises three primary regions: the midbrain, pons, and medulla oblongata.
The Midbrain
The midbrain is located beneath the diencephalon and connects the cerebrum with the lower parts of the brain. The cerebral peduncles are prominent midbrain structures that house the...
The Midbrain
The midbrain is located beneath the diencephalon and connects the cerebrum with the lower parts of the brain. The cerebral peduncles are prominent midbrain structures that house the...
6.0K
Activation Energy
86.4K
Activation energy is the minimum amount of energy necessary for a chemical reaction to move forward. The higher the activation energy, the slower the rate of the reaction. However, adding heat to the reaction will increase the rate, since it causes molecules to move faster and increase the likelihood that molecules will collide. The collision and breaking of bonds represents the uphill phase of a reaction and generates the transition state. The transition state is an unstable high-energy state...
86.4K
What is Energy?
58.5K
The universe is composed of matter in different forms, and all forms of matter contain energy. The different forms of energy on Earth originate from the Sun — the ultimate energy source. Plants capture light energy from the Sun, and, via the process of photosynthesis, convert it into chemical energy. This stored energy from plants can be harnessed in many ways. For example, eating plant products as food provides energy for our body to function, and burning wood or coal (fossilized...
58.5K
Free Energy
51.8K
Free energy—abbreviated as G for the scientist Gibbs who discovered it—is a measurement of useful energy that can be extracted from a reaction to do work. It is the energy in a chemical reaction that is available after entropy is accounted for. Reactions that take in energy are considered endergonic and reactions that release energy are exergonic. Plants carry out endergonic reactions by taking in sunlight and carbon dioxide to produce glucose and oxygen. Animals, in turn, break...
51.8K
Energy Basics
47.3K
Chemical reactions, such as those that occur when you light a match, involve changes in energy as well as matter.
47.3K
Brainstem: Control Centers of Medulla
3.9K
The medulla oblongata is a crucial part of the brainstem responsible for controlling various autonomic and involuntary functions. It contains several nuclei, including the olivary, cuneate, gracile, and solitary nuclei.
Olivary Nucleus
The olivary nucleus, or inferior olivary nucleus, is located within the ventrolateral part of the medulla oblongata. It is primarily involved in motor coordination and motor learning. The olivary nucleus receives input from the spinal cord, cerebellum, and motor...
Olivary Nucleus
The olivary nucleus, or inferior olivary nucleus, is located within the ventrolateral part of the medulla oblongata. It is primarily involved in motor coordination and motor learning. The olivary nucleus receives input from the spinal cord, cerebellum, and motor...
3.9K


