控制视觉指导的行为通过全息回忆的皮质合奏的控制
Luis Carrillo-Reid1, Shuting Han1, Weijian Yang1
1NeuroTechnology Center, Department of Biological Sciences, Columbia University, New York, NY, 10027, USA.
Cell
|July 2, 2019
概括
在小鼠视觉皮层中激活特定的模式完成神经元,因果地将神经元组合与行为联系起来. 这项研究表明,合奏代表知觉状态,并影响视觉任务执行.
科学领域:
- 神经科学是一个神经科学.
- 系统神经科学 系统神经科学
- 计算神经科学是一种神经科学.
背景情况:
- 皮层神经元经常作为合奏一起激活,但它们在行为中的功能作用仍然不清楚.
- 一些神经元表现出模式完成,在刺激时激活整个合奏.
研究的目的:
- 通过激活模式完成神经元来研究神经元组合在行为中的因果作用.
- 为了确定回忆合奏是否会影响视觉任务中的表现.
主要方法:
- 在小鼠的初级视觉皮层中利用了双光子全息光遗传学.
- 在行为相关组合中激活特定模式完成神经元和非选择性神经元.
主要成果:
- 激活非选择性神经元破坏了合奏并降低了行为表现.
- 仅激活两个模式完成神经元,通过可靠地召回合奏来提高性能.
- 不适当地激活合奏引发了不正确的行为选择.
- 没有视觉刺激的合奏激活可以触发正确的行为反应.
结论:
- 神经元组合在视觉引导行为中起因作用.
- 合奏很可能实现感知状态的内部表示.
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