通过黄金对Enynes进行选择性折叠 (I) 具有远程C2Chiral元素的催化剂
Giuseppe Zuccarello1,2, Joan G Mayans1,2, Imma Escofet1,2
1Institute of Chemical Research of Catalonia (ICIQ) , Barcelona Institute of Science and Technology , Av. Països Catalans 16 , 43007 Tarragona , Spain.
Journal of the American Chemical Society
|July 11, 2019
概括
新的黄金 (I) 催化剂能够对1,6-类进行选择性循环. 这些催化剂被用于首次对carexane天然产品的总合成,通过基质折叠来证明对立体化学的控制.
科学领域:
- 有机金属化学
- 不对称的催化
- 自然产品合成
背景情况:
- 催化剂对于不对称的合成至关重要.
- 设计有效的性配体是控制酶选择性的关键.
- 1,6-因是循环反应的多功能基质.
研究的目的:
- 设计具有量身定制的结合腔的新型黄金催化剂.
- 应用这些催化剂对1,6-的选择性循环.
- 实现第一个对护理素天然产品的选择性综合.
主要方法:
- 一个修饰的JohnPhos配体的合成,其中包含一个远端的C2-2,5-diarylpyrrolidine
- 开发了一种奇拉单核黄金的催化剂.
- 催化剂的应用在1,6的5 - exodig和6 - endodig循环中
- 自然产品的立体化学分析和总合成.
主要成果:
- 设计的催化剂有效地促进了对抗选择性5-exo-dig和6-endo-dig循环.
- 成功合成了三种凯雷克桑家族成员的酶选择性总合成.
- 由于基质折叠和-相互作用,在类似反应中证明相反的选择性.
结论:
- 具有C2-基拉元素的新型基拉黄金 (I) 催化剂在1,6-基因循环中提供高的反选择性.
- 催化剂的设计可以精确控制立体化学结果.
- 这项工作促进了非对称催化和天然产品合成.
相关概念视频
Chirality
29.2K
Chirality is a term that describes the lack of mirror symmetry in an object. In other words, chiral objects cannot be superposed on their mirror images. For example, our feet are chiral, as the mirror image of the left foot, the right foot, cannot be superposed on the left foot.
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...
29.2K
Classification of Elements and Compounds
72.9K
Pure substances consist of only one type of matter. A pure substance can be an element or a compound. An element consists of only one type of atom, while a compound consists of two or more types of atoms held together by a chemical bond. Elements are classified as atomic or molecular based on the nature of their basic units.
Compounds are pure substances composed of two or more elements in fixed, definite proportions. Compounds are classified as ionic or molecular (covalent) based on the bonds...
Compounds are pure substances composed of two or more elements in fixed, definite proportions. Compounds are classified as ionic or molecular (covalent) based on the bonds...
72.9K
Protein Folding
126.8K
Overview
126.8K
Protein Folding
11.2K
Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...
Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...
11.2K
Chirality in Nature
16.9K
Chirality is the most intriguing yet essential facet of nature, governing life’s biochemical processes and precision. It can be observed from a snail shell pattern in a macroscopic world to an amino acid, the minutest building block of life. Most of the snails around the world have right-coiled shells because of the intrinsic chirality in their genes. All the amino acids present in the human body exist in an enantiomerically pure state, except for glycine - the sole achiral amino acid.
16.9K
Elements and Compounds
103.3K
Pure substances consist of only one type of matter. A pure substance can be an element or a compound. An element consists of only one type of atom, while a compound consists of two or more types of atoms held together by a chemical bond.
Elements
Elements are classified as atomic or molecular based on the nature of their basic units. They are unique forms of matter with specific chemical and physical properties that cannot break down into smaller substances by ordinary chemical reactions. There...
Elements
Elements are classified as atomic or molecular based on the nature of their basic units. They are unique forms of matter with specific chemical and physical properties that cannot break down into smaller substances by ordinary chemical reactions. There...
103.3K


