斑马鱼的睡眠神经特征
Louis C Leung1, Gordon X Wang1, Romain Madelaine1
1Center for Sleep Sciences and Medicine, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Nature
|July 12, 2019
概括
研究人员发现斑马鱼有两种主要的睡眠特征, 黑色素度激素信号也会影响斑马鱼的睡眠.
科学领域:
- 神经科学
- 比较生物学
- 睡眠研究
背景情况:
- 在哺乳动物,鸟类和中记录了慢波睡眠和快速眼动睡眠的特征.
- 目前尚不清楚非乳房脊椎动物是否存在类似的神经睡眠特征.
- 斑马鱼是研究脊椎动物生物学和神经科学的关键模型生物.
研究的目的:
- 调查斑马鱼的睡眠特征的存在和性质,
- 探索脊椎动物睡眠模式的演化起源.
- 确定斑马鱼睡眠调节的分子通路.
主要方法:
- 为斑马鱼开发基于光的非侵袭性多睡眠学.
- 没有偏见,全脑活动记录.
- 同时评估眼动,肌肉动态和心率.
主要成果:
- 在斑马鱼中发现至少两种主要的睡眠特征:缓慢爆发的睡眠和传播波浪的睡眠.
- 这些特征与哺乳动物的慢波睡眠和悖论性 (REM) 睡眠有共同点.
- 黑色素度激素信号调节斑马鱼的传播波睡眠和整体睡眠时间,可能通过表皮细胞.
结论:
- 在4亿5千万年前, 脊椎动物大脑中出现了共同的神经信号.
- 斑马鱼的睡眠模式与哺乳动物相似.
- 在脊椎动物的睡眠调节中保留了黑色素度激素通路.
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