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Updated: Jan 22, 2026

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia
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Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia

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从人造心脏组织中了解 катехоламинергия多态心室慢心病的发病原因

Sung-Jin Park1, Donghui Zhang2,3, Yan Qi2

  • 1Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences (S.-J.P., K.Y.L., S.L.K., F.S.P., P.H.C., K.K.P.), Harvard University, Cambridge, MA.

Circulation
|July 18, 2019
PubMed
概括

这项研究开发了一种针对多样性心室高心率 (CPVT) 的人体工程心脏组织模型. 该模型揭示了一个关键的酸化事件,导致组织水平上的心律失常,进步了解遗传性心律失常.

关键词:
没有.心律不整,心脏病生物工程甲基胺多态心室动脉障碍病模型基因编辑干细胞

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