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与人血清白蛋白复合的1,18- 八度甘酸- 帕克利塔塞尔的抗瘤活性

Cassandra E Callmann1,2, Clare L M LeGuyader1, Spencer T Burton2

  • 1Department of Chemistry & Biochemistry , University of California San Diego , La Jolla , California 92093 , United States.

Journal of the American Chemical Society
|July 19, 2019
PubMed
概括

一种新的帕克利塔塞尔 (PTX) 前药物ODDA-PTX利用人体血清白蛋白 (HSA) 来改善药物输送. 这种结合白蛋白的策略在临床前癌症模型中提高了抗瘤功效和耐受性.

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