哺乳动物性别偏差基因表达的保存,获取和功能影响
Sahin Naqvi1,2, Alexander K Godfrey1,2, Jennifer F Hughes1
1Whitehead Institute, Cambridge, MA 02142, USA.
概括
基因表达的性别差异存在于各种物种和组织中,有助于高度等特征. 然而,大多数性别特异性基因表达在哺乳动物辐射过程中进化,因此在使用人类性别差异的动物模型时需要谨慎.
科学领域:
- 基因组学
- 比较生物学
- 分子生物学
背景情况:
- 性差异在人类的健康和疾病中很普遍.
- 这些分子性别差异在物种和组织中的保存在很大程度上是未知的.
- 哺乳动物模型经常用于研究人类的性别差异.
研究的目的:
- 在多种物种和组织中研究基因表达的性别差异程度.
- 确定保存的性别偏差基因表达对表型差异的贡献,例如人类身高.
主要方法:
- 在人类,,老鼠和狗中调查基因表达的性别差异.
- 分析了每个物种的12种不同组织中的基因表达.
- 对人类身高数据进行基因组分析.
主要成果:
- 在每一个组织中都发现了数百个基因的性别偏差表达.
- 保存的性别偏差基因表达以及基因组数据解释了男性和女性身高差异的约12%.
- 大多数性别偏差的基因表达模式起源于哺乳动物辐射期.
结论:
- 在基因表达中保留的性别偏见有助于各种特征的性别差异.
- 哺乳动物进化过程中发生了性别偏差基因表达的显著分歧.
- 在使用动物模型研究人类性别差异时,仔细考虑物种间的差异至关重要.
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