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混凝土,双化摩根菌重复单元的总合成
D Jamin Keith1, Steven D Townsend1
1Department of Chemistry , Vanderbilt University , Nashville , Tennessee 37235 , United States.
Journal of the American Chemical Society
|July 23, 2019
概括
研究人员从Morganella morganii中合成了一种新的zwitterionic多糖体 (ZPS) 重复单元. 这一突破可以创造出具有独特免疫调节特性的新型ZPS材料.
科学领域:
- 碳水化合物化学
- 免疫学
- 合成生物学
背景情况:
- 已知Zwitterionic多糖体 (ZPSs) 通过MHCII类表达激活T细胞依赖的免疫反应.
- 复杂的ZPS结构的合成对于开发具有免疫调节功能的新生物材料至关重要.
研究的目的:
- 报告第一个Morganella morganii ZPS重复单元的合成.
- 为新型ZPS材料建立一个多功能合成工具.
- 调查ZPS结构中独特的功能组的结合.
主要方法:
- 使用第三代合成方法.
- 为糖醇功能化受体开发了一种新型的糖化方法.
- 合成了一种高效的胆供体,
主要成果:
- 已经成功合成了摩根氏菌ZPS重复单元.
- 包含一个1,2-cis-α-glycosidic键和一个具有挑战性的1,2-trans-galactosidic键 (Gal-β-(1 → 3) -GalNAc).
- 首次在同一个寡糖体上同时安装糖和胆残留物.
结论:
- 开发的合成策略为构建复杂的ZPS提供了有价值的工具.
- 合成的重复单元有助于在免疫学中创造新的ZPS材料.
- 这项工作扩大了可访问的ZPS结构及其功能化.
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