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通过T细胞调节微生物群,防止肥胖

Charisse Petersen¹, Rickesha Bell¹, Kendra A Klag¹

¹Department of Pathology, Division of Microbiology and Immunology, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.

Science (New York, N.Y.)

|July 27, 2019

概括

有益的Clostridia细菌通过调节脂质吸收来预防代谢综合征. 免疫系统对这些微生物的向和有害Desulfovibrio的扩散促进了肥胖.

科学领域:

微生物组研究
免疫学
代谢综合征

背景情况:

肠道微生物群在肥胖中起作用,
在宿主微生物群相互作用的研究中观察到与年龄相关的代谢综合征 (MetS).
这种模型中的肥胖与Desulfovibrio的扩张和Clostridia的丧失有关,类似于人类的MetS.

研究的目的:

研究特定肠道细菌在预防代谢综合征中的作用.
了解免疫反应如何影响肠道微生物组成和代谢健康.

主要方法:

在与年龄相关的代谢综合征模型中研究了宿主微生物群相互作用.
分析了微生物组成 (Desulfovibrio,Clostridia) 和宿主免疫反应 (T细胞,免疫球蛋白A).
进行转录和代谢分析以评估脂质吸收和基因调节.

主要成果:

扩大Desulfovibrio和失去Clostridia与肥胖和MetS有关.
需要依赖T细胞的免疫事件来预防疾病.
不适当的免疫球蛋白A对克洛斯特里迪亚的向和增加的Desulfovibrio抑制了有益的克洛斯特里迪亚殖民.
肥胖的主体显示脂肪吸收增强.
使用Clostridia,但不使用Desulfovibrio,降低脂肪和降低脂质吸收基因.

结论:

对于维持有益的Clostridia种群而言,对微生物群的免疫控制至关重要.
这些有益的微生物限制脂质代谢,从而防止代谢综合征.
针对特定的微生物群体及其与免疫系统的相互作用,可能为肥胖和METS提供治疗策略.

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