皮肤TRPV1+ 神经元触发保护性 17型先天性免疫
Jonathan A Cohen1, Tara N Edwards1, Andrew W Liu1
1Department of Dermatology, University of Pittsburgh, Pittsburgh, PA 15261, USA; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Cell
|July 30, 2019
概括
激活感官神经元 (TRPV1+) 足以启动天生的免疫反应, 增强皮肤对病原体的防御能力. 这种神经元激活也通过神经反射保护附近的皮肤.
科学领域:
- 免疫学
- 神经科学
- 皮肤病学
背景情况:
- 皮肤TRPV1+神经元检测有害刺激,对于对皮肤病原体的先天免疫是至关重要的.
- 单独激活TRPV1+神经元的免疫反应能力及其功能作用尚不清楚.
研究的目的:
- 调查TRPV1+神经元的激活是否足以启动先天免疫反应.
- 确定TRPV1+神经元触发的免疫反应的生物功能.
主要方法:
- 通过光刺激利用TRPV1-Ai32光遗传小鼠进行向性皮肤神经元激活.
- 在没有组织损伤或病原体相关分子的情况下进行实验,以分离神经元激活的影响.
主要成果:
- 单独的TRPV1+神经元激活成功启动了局部17型免疫反应.
- 这种反应增强了宿主对*C. albicans*和*S. aureus*皮肤感染的防御能力.
- 神经元激活也诱导了17型反应,并通过神经反射弧加强了邻近的非刺激皮肤的防御.
结论:
- TRPV1+神经元的激活足以引起天生的免疫反应并增强宿主防御.
- 在邻近的皮肤部位表现出预先天生的免疫力,由抗神经元激活介导.
- 在皮肤中建立了神经元激活和先天免疫系统调节之间的功能联系.
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