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相关概念视频

Introduction to Innate and Adaptive Immunity01:21

Introduction to Innate and Adaptive Immunity

9.0K
The human immune system is a complex defense mechanism that protects the body from harmful pathogens and foreign substances. It comprises two crucial components: innate and adaptive immunity.
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
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Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

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The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
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What is the Immune System?01:38

What is the Immune System?

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Overview
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Nervous Tissue: Neuron Types01:19

Nervous Tissue: Neuron Types

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Neurons, the fundamental units of the nervous system, can be classified based on both their structural and functional characteristics.
Structurally, neurons are categorized into three main types: multipolar, bipolar, and unipolar (or pseudounipolar). Multipolar neurons, which are the most common type in the brain and spinal cord, as well as all motor neurons, possess multiple dendrites and a single axon.
Bipolar neurons, on the other hand, have one primary dendrite and one axon. They are...
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Zones of Protection01:16

Zones of Protection

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In power systems, the entire setup is divided into protective zones to isolate faults and protect the rest of the network. These zones include generators, transformers, buses, transmission lines, distribution lines, and motors. Each zone can be visualized as a separate room in a house, with each room protected by its own circuit breaker.
Protective zones are defined by closed dashed lines, containing one or more components. A key characteristic of these zones is the strategic placement of...
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Protection of Alcohols02:31

Protection of Alcohols

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This lesson delves into the concept of protection and deprotection of a functional group fundamental to synthetic organic chemistry. These phenomena are explained in the context of aliphatic and aromatic alcohols.
Protection
It defines a protecting group as the masking agent to make the more reactive species inert to a given set of conditions. This concept is depicted via the illustration of liquid flow through different outlets in an assembly of pipes. The analogy helps to understand the role...
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这页已由机器翻译。其他页面可能仍然显示为英文。View in English
  1. 首页
  2. 研究领域
  3. 生物医学和临床科学
  4. 神经科学
  5. 感官系统
  6. 皮肤trpv1+ 神经元触发保护性 17型先天性免疫

皮肤TRPV1+ 神经元触发保护性 17型先天性免疫

Jonathan A Cohen1, Tara N Edwards1, Andrew W Liu1

  • 1Department of Dermatology, University of Pittsburgh, Pittsburgh, PA 15261, USA; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA.

Cell
|July 30, 2019

相关实验视频

Author Spotlight: Establishing Mixed Neuronal and Glial Cell Cultures from Embryonic Mouse Brains to Study Infection and Innate Immunity
07:41

Author Spotlight: Establishing Mixed Neuronal and Glial Cell Cultures from Embryonic Mouse Brains to Study Infection and Innate Immunity

Published on: June 30, 2023

3.6K
Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
08:32

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production

Published on: March 2, 2014

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Evaluation of Caspase Activation to Assess Innate Immune Cell Death
10:23

Evaluation of Caspase Activation to Assess Innate Immune Cell Death

Published on: January 20, 2023

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在PubMed 上查看摘要

概括
此摘要是机器生成的。

激活感官神经元 (TRPV1+) 足以启动天生的免疫反应, 增强皮肤对病原体的防御能力. 这种神经元激活也通过神经反射保护附近的皮肤.

科学领域:

  • 免疫学
  • 神经科学
  • 皮肤病学

背景情况:

  • 皮肤TRPV1+神经元检测有害刺激,对于对皮肤病原体的先天免疫是至关重要的.
  • 单独激活TRPV1+神经元的免疫反应能力及其功能作用尚不清楚.

研究的目的:

  • 调查TRPV1+神经元的激活是否足以启动先天免疫反应.
  • 确定TRPV1+神经元触发的免疫反应的生物功能.

主要方法:

  • 通过光刺激利用TRPV1-Ai32光遗传小鼠进行向性皮肤神经元激活.
  • 在没有组织损伤或病原体相关分子的情况下进行实验,以分离神经元激活的影响.

主要成果:

  • 单独的TRPV1+神经元激活成功启动了局部17型免疫反应.
  • 这种反应增强了宿主对*C. albicans*和*S. aureus*皮肤感染的防御能力.
  • 神经元激活也诱导了17型反应,并通过神经反射弧加强了邻近的非刺激皮肤的防御.

结论:

  • TRPV1+神经元的激活足以引起天生的免疫反应并增强宿主防御.
  • 在邻近的皮肤部位表现出预先天生的免疫力,由抗神经元激活介导.
关键词:
其他:美国CGRP黄金一个TRPV

相关实验视频

Author Spotlight: Establishing Mixed Neuronal and Glial Cell Cultures from Embryonic Mouse Brains to Study Infection and Innate Immunity
07:41

Author Spotlight: Establishing Mixed Neuronal and Glial Cell Cultures from Embryonic Mouse Brains to Study Infection and Innate Immunity

Published on: June 30, 2023

3.6K
Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
08:32

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production

Published on: March 2, 2014

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Evaluation of Caspase Activation to Assess Innate Immune Cell Death
10:23

Evaluation of Caspase Activation to Assess Innate Immune Cell Death

Published on: January 20, 2023

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  • 在皮肤中建立了神经元激活和先天免疫系统调节之间的功能联系.
  • 抗氧化剂
    主机防御
    天生的免疫力
    神经免疫学
    视觉遗传学
    皮肤