短波红外成像用J-聚合物稳定在空心半孔纳米颗粒
Wei Chen, Chi-An Cheng, Emily D Cosco1
1Helmholtz Pioneer Campus, Helmholtz Zentrum München , D-85764 Neuherberg , Germany.
Journal of the American Chemical Society
|July 30, 2019
概括
研究人员开发了用于短波红外 (SWIR) 成像的新纳米材料. 这些J-聚合物纳米粒子能够实现高分辨率的体内成像,克服当前对比剂的局限性.
科学领域:
- 生物医学光学
- 材料科学
- 纳米技术
背景情况:
- 组织对短波红外光 (SWIR) 的透明度使光学成像在这个频谱中具有优势.
- 目前在SWIR光学成像中的局限性是由于发射超过1000nm的明亮,生物相容的对比剂的稀缺性.
研究的目的:
- 开发用于增强SWIR光学成像的新型纳米材料.
- 通过J聚合,从近红外 (NIR) 光体中制造红移SWIR对比剂.
主要方法:
- 在空心半孔纳米颗粒 (HMSN) 中制备NIR化物IR-140的J聚合物.
- 封装J聚合物的HMSN的PEGylation.
- 在缓冲中评估纳米材料的稳定性.
- 使用980nm激发的体内成像研究.
主要成果:
- 通过在HMSN中封装IR-140 J聚合物,成功合成吸收和发射SWIR光的纳米材料.
- 含有J聚合物的PEGylated HMSN在缓冲剂中表现为稳定数周.
- 使用开发的纳米材料实现了高分辨率的体内成像,980nm激发.
结论:
- 在HMSN中进行J聚合是创建红移SWIR对比剂的有效策略.
- 开发的基于PEGylated HMSN的纳米材料是稳定的,适用于高分辨率的体内SWIR成像.
- 这些发现解决了需要先进的对比剂来扩大SWIR光学成像的效用.
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