作为协作工具的总合成
Lucas A Morrill1, Robert B Susick1, Jason V Chari1
1Department of Chemistry and Biochemistry , University of California , Los Angeles , California 90095 , United States.
Journal of the American Chemical Society
|July 30, 2019
概括
总合成是越来越多的协作, 混合方法如生物催化和计算化学. 这种观点突出了最近的合作复杂分子合成和历史例子.
科学领域:
- 有机化学
- 医学化学
- 生物化学
背景情况:
- 总体综合通常被认为是竞争性的,而不是协作性的.
- 最近的进展正在促进复杂分子合成的跨学科合作.
研究的目的:
- 总结最近的合作努力.
- 展示各种科学领域在复杂分子合成中的融合.
- 讨论合作的历史背景.
主要方法:
- 关于合作总合成项目的最新文献的审查.
- 合成方法,生物催化,生物合成,计算化学和药物发现的整合分析.
- 具体案例研究的讨论,包括chloroissoclimide,nigelladine A,artemisinin,ingenol,hippolachnin A,communesin A和citrinalin B.
- 关于维生素B12合成的伍德沃德-埃申莫瑟合作的历史审查.
主要成果:
- 复杂的自然产品的成功合作合成证明了跨学科方法的力量.
- 多种技术的整合提高了总合成的效率和范围.
- 历史上的合作, 比如维生素B12, 奠定了现代努力的基础.
结论:
- 协作是现代综合学的重要趋势.
- 跨学科的方法对于解决复杂的分子目标至关重要.
- 整体合成的未来在于战略合作.
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