人类胎盘没有微生物群,但可能含有潜在的病原体
Marcus C de Goffau1,2, Susanne Lager3,4,5, Ulla Sovio3,4
1Wellcome Sanger Institute, Cambridge, UK.
Nature
|August 2, 2019
概括
人类胎盘缺乏微生物群,除了Streptococcus agalactiae外,它通常不会受到细菌的感染. 细菌存在与妊娠前等不良结果无关.
科学领域:
- 微生物学
- 妇产科
- 新生儿健康
背景情况:
- 妊娠前,早产和胎儿生长受限等不良结果是令人担忧的.
- 胎盘微生物组在妊娠并发症中的作用仍在争论中.
- 之前的研究对胎盘组织中的细菌存在产生了相互矛盾的结果.
研究的目的:
- 研究胎盘中的细菌DNA与不良妊娠结果之间的关联.
- 为了确定人类的胎盘是否有独特的微生物组.
- 在胎盘样本中识别特定的细菌物种,如果有的话.
主要方法:
- 使用分子技术分析有并发症和没有并发症的胎盘样本.
- 严格的方法来区分真正的细菌信号和实验室污染.
- 在分娩前收集的胎盘组织中检测细菌DNA.
主要成果:
- 大多数胎盘样本都没有细菌存在的证据.
- 检测到的细菌信号主要归因于分娩期间的污染或获取.
- 在约5%的产前样本中检测到Streptococcus agalactiae (B组Streptococcus),这表明潜在的产周获取地点.
结论:
- 胎盘的细菌感染不是妊娠不良结果的常见原因.
- 人类的胎盘没有微生物组.
- 胎盘可以作为Streptococcus agalactiae的围产部,这是新生儿败血症的重要原因.
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