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驱动过敏性IgE的T毛囊辅助细胞子集的鉴定

Uthaman Gowthaman^1,2, Jennifer S Chen^1,2, Biyan Zhang^1,2

¹Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.

Science (New York, N.Y.)

|August 3, 2019

概括

一种罕见的T毛囊辅助13 (T_FH13) 细胞子集产生中白蛋白-13 (IL-13) 驱动高亲和力免疫球蛋白E (IgE) 的产生和过敏反应. 阻断这些T_FH13细胞可能为过敏提供一种新的治疗策略.

科学领域:

免疫学
对过敏的研究
细胞机制

背景情况:

过敏是一种严重的过敏反应,由高亲和力免疫球蛋白E (IgE) 的交叉链接引发.
对于B细胞在对过敏原的反应中产生IgE的确切细胞机制尚未完全理解.
已知T毛囊辅助细胞 (T_FH) 调节抗体的产生,但驱动IgE合成的特定因素仍然难以捉摸.

研究的目的:

确定参与诱导高亲和性IgE产生的新型细胞参与者.
阐明导致过敏原特异性IgE合成和随后的过敏反应的机制.
探索潜在的新治疗点来治疗过敏反应.

主要方法:

对小鼠和人类不同水平的过敏原特异性IgE的T毛囊辅助细胞 (T_FH) 种群的分析.
鉴定T_FH子组中的细胞因子概况和转录因子表达.
功能性研究以评估特定T_FH群体在IgE产生和过敏反应中的作用.

主要成果:

发现了一种罕见的T_FH亚群,称为T_FH13细胞,其特征是IL-13,IL-4和IL-5的高表达和IL-21的低表达.
T_FH13细胞共同表达转录因子BCL6和GATA3.
这些T_FH13细胞在具有高亲和性IgE的个体中发现,但在具有低亲和性或没有特定IgE的个体中没有发现.
对于高亲和性IgE的产生和过敏原诱导的过敏反应,T_FH13细胞是必不可少的,而对于低亲和性IgE则不是.

结论:

一个独特的T_FH13细胞群对于高亲和性IgE和过敏反应的发展至关重要.
向T_FH13细胞为预防或治疗过敏症提供了潜在的新疗法.
对T_FH13细胞生物学的进一步研究可能会发现过敏免疫治疗的新策略.

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