实验室小鼠出生于野生小鼠,具有自然的微生物群,并模仿人类的免疫反应

Stephan P Rosshart1, Jasmin Herz2, Brian G Vassallo3

  • 1Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, MD 20892, USA. stephan.rosshart@uniklinik-freiburg.de rehermann@nih.gov.

Science (New York, N.Y.)
|August 3, 2019
PubMed
概括

介绍一下"野鼠",一种新型的小鼠模型, 结合了野鼠微生物群和C57BL/6基因. 这种模型提高了免疫反应的准确性和生物医学研究中的翻译价值.

相关概念视频

Humoral Immune Responses01:36

Humoral Immune Responses

Overview
83.4K
The Born-Haber Cycle02:44

The Born-Haber Cycle

Lattice Energy 
25.2K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
83.6K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
8.5K
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
1.8K
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
8.8K