便微生物种植的使用演变和新出现的治疗指示
Jessica R Allegretti1, Benjamin H Mullish2, Colleen Kelly3
1Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Lancet (London, England)
|August 6, 2019
概括
高通量测序揭示了疾病中的肠道微生物群变化,但因果关系尚不清楚. 便微生物移植有望恢复肠道健康并治疗C. difficile等感染.
科学领域:
- 微生物学
- 基因组学
- 系统生物学
背景情况:
- 高通量测序和系统生物学提供了关于肠道微生物群在健康和疾病中的作用的见解.
- 在许多疾病中观察到肠道微生物组成和功能的独特变化,但它们之间的因果关系仍然不确定.
研究的目的:
- 探索调节肠道微生物群的潜在治疗应用.
- 突显便微生物移植在临床和研究环境中的日益重要.
主要方法:
- 对肠道微生物群在健康和疾病中的现有理解进行审查.
- 检查便微生物移植作为治疗策略.
主要成果:
- 目前,对于复发的Clostridioides difficile感染,建议进行便微生物移植.
- 许多临床试验正在研究其他潜在的治疗适用性.
结论:
- 肠道微生物群在疾病中的作用需要进一步研究以确定因果关系.
- 便微生物移植是除了困难菌感染之外的各种疾病的有希望的治疗方法.
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