胰腺癌查:美国预防服务工作组的最新证据报告和系统审查
Nora B Henrikson1, Erin J Aiello Bowles1, Paula R Blasi1
1Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Research Affiliates Evidence-based Practice Center, Seattle.
JAMA
|August 7, 2019
概括
使用成像检查高风险个体的胰腺癌可以在最小的危害下检测出疾病. 然而,查对这些群体的生存率和治疗效果的影响尚未研究.
科学领域:
- 癌症学
- 预防医学
- 诊断成像
背景情况:
- 胰腺腺癌是美国癌症死亡的主要原因.
- 需要有效的查策略来改善患者的治疗结果.
研究的目的:
- 系统地审查胰腺腺癌查的益处和危害.
- 为美国预防服务工作组 (USPSTF) 的建议提供信息.
主要方法:
- 对MEDLINE,PubMed和Cochrane图书馆 (2002-2019) 的系统审查.
- 包括成年人具有或没有危险因素的成像查研究.
- 不包括遗传综合征的研究.
主要成果:
- 在高家族风险人群中进行了13项相当优质的队列研究 (N=1317).
- 通过内镜超声波,MRI或CT进行查,每1000人中有0-75例.
- 没有关于查对发病率/死亡率或治疗有效性的研究报告.
- 报告的程序和心理伤害最小.
结论:
- 基于成像的查可以在低危险的高风险群体中检测胰腺癌.
- 查对生存的影响缺乏证据.
- 对于平均风险人群和治疗有效性的数据是不够的.
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