在水中模仿超分子共聚物的自组糖囊中阐明排序
Simone I S Hendrikse1, Lu Su1, Tim P Hogervorst2
1Institute for Complex Molecular Systems , Eindhoven University of Technology , P.O. Box 513, 5600 MB Eindhoven , The Netherlands.
Journal of the American Chemical Society
|August 8, 2019
概括
新的-1,3,5-三胺 (BTA) 单体与碳水化合物附件可以控制超分子组合. 这样可以制造具有调节性质的1D纤维和水凝等功能性生物材料.
科学领域:
- 超分子化学
- 生物材料科学
- 碳水化合物化学
背景情况:
- 多糖对于生物功能和生物材料的发展至关重要.
- 生物材料中的多糖体的空间功能化具有挑战性.
- 基于-1,3,5-三胺 (BTA) 的超分子单体为功能化提供了一个平台.
研究的目的:
- 设计和合成新的糖化BTA单体.
- 调查碳水化合物附属物对超分子组合的影响.
- 开发具有可调节性质的功能生物材料.
主要方法:
- 用单糖和分糖合成BTA单体
- 超分子组装行为的特征 (1D纤维,小粒).
- 用BTA单体的共聚化来控制糖密度和特性.
主要成果:
- 碳水化合物自然要求高分子聚合.
- BTA-Glc和BTA-Man形成螺旋式1D纤维; BTA-Cel和BTA-OEG4-Man形成.
- 同聚合产生1D纤维,含有可调的糖和动态交换.
结论:
- 糖化BTA单体可以控制自身组装.
- 在1D纤维中可以实现可调的糖密度.
- 能够开发功能性生物材料,包括可调节的水凝.
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