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Updated: Jan 21, 2026

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一种主导负效应驱动了骨髓瘤中TP53错误突变的选择

Steffen Boettcher1,2,3, Peter G Miller1,2,3, Rohan Sharma2,3

  • 1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

Science (New York, N.Y.)
|August 10, 2019
PubMed
概括

瘤抑制基因TP53在癌症中经常发生突变,主要表现出主导负效应 (DNE),而不是功能增强 (GOF) 活性. 这种DNE在某些癌症中为TP53误解突变提供了选择性优势.

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