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Updated: May 3, 2026

Fractionation for Resolution of Soluble and Insoluble Huntingtin Species
07:08

Fractionation for Resolution of Soluble and Insoluble Huntingtin Species

Published on: February 27, 2018

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CAG重复不多胺的长度决定了亨廷顿病的发病时间

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    Cell
    |August 10, 2019
    PubMed
    概括

    亨廷顿病 (HD) 的发病不仅取决于多重胺片长. 相反,由DNA维护基因影响的HTT CAG重复序列的不稳定性推动了疾病的进展.

    关键词:
    CAG重复表示DNA 的维护DNA 修复亨廷顿病开始时的年龄疾病变异基因修饰剂多重胺的疾病身体DNA扩张三核酸重复

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    Efficient and Scalable Production of Full-length Human Huntingtin Variants in Mammalian Cells using a Transient Expression System10:52

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