运动诱导的心脏热I增加和事件死亡率和心血管事件
Vincent L Aengevaeren1,2, Maria T E Hopman1, Paul D Thompson3
1Departments of Physiology (V.L.A., M.T.E.H., E.A.B., D.H.J.T., T.M.H.E.), Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Circulation
|August 13, 2019
概括
长途行走后心脏素I水平升高预示着老年人死亡率和心血管事件的增加. 这表明运动引起的热激素增加可能是未来健康风险的信号, 而不是良性反应.
科学领域:
- 心脏病学
- 运动生理学
- 生物标志物
背景情况:
- 对于诊断急性心肌损伤和心脏梗塞而言,心脏素升高至99百分位以上至关重要.
- 即使低于99分之一值, 热素水平也预示着不良结果.
- 运动诱导的热激素增加的临床意义仍然不清楚,特别是在耐力运动后.
研究的目的:
- 在长途步行者中,研究运动后心脏托罗I度与临床结果之间的联系.
- 为了确定运动诱导的热血素升高是否预测心血管不良事件和死亡率.
主要方法:
- 在步行30-55公里之前和之后,对725名参与者进行了心脏素I测量.
- 这项研究评估了99百分位以上的运动后热血素I与死亡率和主要心血管不良事件的复合终点之间的关联.
- 随访时间平均为43个月,并根据心血管风险因素和先前病情进行调整.
主要成果:
- 在行走后,I型热素水平显著增加 (P<.001).
- 9% 的参与者 (63/ 725) 的运动后热血素I > 0. 040 μg/ L.
- 运动后肌I水平升高的参与者出现复合终点的发生率显著高 (27% vs 7%,日志等级P<. 001),危险比为2. 48 (95% CI,1. 29-4. 78).
结论:
- 在长时间行走后,运动诱导的I型热血素升高超过99个百分位, 独立预测死亡率和心血管事件的增加.
- 这些发现表明运动诱导的素增加可能不是良性的生理反应.
- 运动后热水平升高可能成为老年人未来不良健康状况的早期标志.
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