长期暴露于环境空气污染和量化评估的肺和肺功能之间的关联
Meng Wang1,2,3, Carrie Pistenmaa Aaron4, Jaime Madrigano5,6
1Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle.
JAMA
|August 14, 2019
概括
长期暴露于臭氧 (O3),细颗粒物 (PM2.5) 和氧化 (NOx) 等空气污染物与肺瘤恶化和肺功能下降有关. 这项研究强调了当代空气污染水平对呼吸系统的健康风险.
科学领域:
- 环境健康
- 肺部医学
- 流行病学
背景情况:
- 历史上的空气污染与心血管和呼吸系统疾病有关.
- 目前尚不清楚当代空气污染物度与肺瘤进展之间的关联.
研究的目的:
- 评估环境臭氧 (O3),细颗粒物 (PM2.5),氧化物 (NOx) 和黑碳暴露与肺变化的纵向关联.
- 评估空气污染物对长期肺功能的影响.
主要方法:
- 来自多民族动脉样硬化 (MESA) 空气和肺部研究 (2000-2018) 的7071名成年人的队列研究.
- 经过验证的时空模型估计了特定住所的空气污染物度.
- 通过CT扫描评估肺的百分比,并使用螺旋计测量肺功能.
主要成果:
- 长期暴露于O3,PM2.5,NOx和黑碳与10年内肺气的百分比增加有关.
- 在随访期间的O3和NOx暴露也与肺气的更大进展相关.
- 氧3暴露与1秒内强制呼气量 (FEV1) 的显著下降有关.
结论:
- 长期暴露于环境空气污染物与肺的进展和肺功能减弱有显著联系.
- 这些发现强调了减少对常见空气污染物的暴露对呼吸系统健康的重要性.
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