由奥斯莫利特产生的冷保护和奥斯摩保护的常见来源
Roy Govrin1, Tal Obstbaum1, Uri Sivan1
1Department of Physics and the Russell Berrie Nanotechnology Institute , Technion - Israel Institute of Technology , Technion City, Haifa 3200003 , Israel.
Journal of the American Chemical Society
|August 15, 2019
概括
通过抵消低温对充电表面的影响,保护细胞免受寒冷压力. 这些化合物既能起到冷保护作用, 又能起到透保护作用,
科学领域:
- 生物物理
- 生物化学
- 细胞生物学
背景情况:
- 研究已经明确了高盐度对库伦相互作用的奥斯莫利特效应.
- 对于化过程中化物对这些相互作用的影响的了解有限.
研究的目的:
- 研究低温对含盐和奥斯莫利特溶液中充电表面之间的库伦相互作用的影响.
- 阐明奥斯莫利特对冷引起的表面电荷变化的保护机制.
主要方法:
- 在不同温度下的三元溶液 (盐和溶液) 中探测带电表面相互作用.
- 对离子吸附和表面电荷中和/再充电的分析.
主要成果:
- 低温通过增加对电离子吸附来模仿多余的盐,中和充电的表面.
- 通过释放被吸收的对子离子,从而重新充电表面,证明了proline和glycine- betaine可以逆转这种效应.
- 这种对抗机制解释了这些氧体的冷保护和氧保护作用.
结论:
- 这项研究揭示了氧化物抵消冷引起的表面电荷中和, 作为有效的冷保护剂.
- 这种机制解释了面临寒冷或干旱压力的生物体的积.
- 通过调节库伦相互作用,和甘氨酸-贝他因表现为冷保护剂和 osmoprotectants 的双重作用.
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