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GPCR激素的O-GlcNAc工程改善了它们的稳定性和活体活性

Paul M Levine, Aaron T Balana, Emmanuel Sturchler1

  • 1Department of Molecular Medicine The Scripps Research Institute , Jupiter , Florida 33458 , United States.

Journal of the American Chemical Society
|August 17, 2019
PubMed
概括

O- GlcNAcylation增强了GLP- 1和PTH等治疗性的稳定性和体内活性. 这种新的方法克服了的不稳定性,为开发改进的疗法提供了有希望的策略.

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