在液体染色学中使用同体性金属有机框架进行反选择性分离
M Nieves Corella-Ochoa1, Jesús B Tapia, Heather N Rubin
1Institute of Chemical Research of Catalonia (ICIQ) , The Barcelona Institut of Science and Technology (BIST) , Av. Països Catalans 16 , Tarragona E-43007 , Spain.
Journal of the American Chemical Society
|August 21, 2019
概括
一个新的多孔,坚固的同体基质金属有机框架 (MOF),TAMOF-1,为工业规模的反体分离提供了成本有效的解决方案. 这种材料具有广泛的适用性,并且优于现有的性染色学方法.
科学领域:
- 材料科学
- 有机化学
- 化学工程
背景情况:
- 选择性分离对制药行业至关重要.
- 目前的静止体相很昂贵,缺乏强度,并且具有有限的多功能性.
- 与工业规模的化净化相关的高成本阻碍了广泛应用.
研究的目的:
- 开发一种新的,经济高效的,强大的分离材料.
- 评估新材料在各种溶剂和奇拉分析剂中的性能.
- 解决现有的性分离技术的局限性.
主要方法:
- 使用铜 (II) 和由l-histidine衍生的连接剂合成一个多孔,坚固的同体基质金属有机框架 (MOF),TAMOF-1.
- 测试TAMOF-1在分离包括药物化合物在内的多种模型血混合物的有效性.
- 在高性能液体染色学 (HPLC) 中对TAMOF-1性能进行比较分析.
主要成果:
- TAMOF-1成功分离了包括药物在内的各种模型血混合物.
- 这种材料在广泛的溶剂极性中表现出有效性.
- 与几种商业化华LC列相比,TAMOF- 1 的性能更为优异.
- TAMOF-1 的合成可扩展到多公斤的数量.
结论:
- TAMOF-1是一个有前途的,负担得起的,多功能替代传统的静止阶段.
- TAMOF-1的可扩展性和性能为低能耗,工业规模的奇拉分离提供了可能性.
- 这种发展可以显著降低成本,提高制药行业的性净化效率.
相关概念视频
High-Performance Liquid Chromatography: Introduction
3.4K
High-performance liquid chromatography(HPLC), formerly referred to as High-pressure liquid chromatography, is a powerful technique used to separate, identify, and quantify components in complex mixtures. The term "high pressure" refers to using high pressure to push the liquid mobile phase through the tightly packed columns.
In HPLC, two phases play a critical role in the separation process:
In HPLC, two phases play a critical role in the separation process:
3.4K
High-Performance Liquid Chromatography: Instrumentation
2.9K
High-performance liquid chromatography, or HPLC, is an analytical technique that separates liquid samples under high pressures. An HPLC instrument consists of glass bottles for storing solvents called mobile phase reservoirs. HPLC-grade solvents are used to maintain high purity, and the dissolved gases are removed using a degasser, such as a vacuum pumping system or sparging with helium. The solvents are then pumped into the analytical column using a screw-driven syringe or reciprocating pumps.
2.9K
High-Performance Liquid Chromatography: Elution Process
1.4K
In High-Performance Liquid Chromatography (HPLC), the elution process is critical to the separation of analytes and the quality of chromatographic results. Elution describes how compounds move through the column and separate based on their interactions with the mobile and stationary phases. This process determines the resolution, peak shape, and retention times in the chromatogram, which are essential for identifying and quantifying components in complex mixtures. Understanding the elution...
1.4K
High-Performance Liquid Chromatography: Types of Detectors
1.6K
The role of the detectors in High-Performance Liquid Chromatography (HPLC) is to analyze the solutes as they exit from the chromatographic column. The detector recognizes the solute's property and generates corresponding electrical signals, which are converted into a readable graph of the detector's response versus elution time called a chromatogram at the computer. There are several types of HPLC detectors, each with its own advantages and limitations, depending on the analyte...
1.6K
Bonding in Metals
52.1K
Metallic bonds are formed between two metal atoms. A simplified model to describe metallic bonding has been developed by Paul Drüde called the “Electron Sea Model”.
52.1K
Metallic Solids
20.5K
Metallic solids such as crystals of copper, aluminum, and iron are formed by metal atoms. The structure of metallic crystals is often described as a uniform distribution of atomic nuclei within a “sea” of delocalized electrons. The atoms within such a metallic solid are held together by a unique force known as metallic bonding that gives rise to many useful and varied bulk properties.
All metallic solids exhibit high thermal and electrical conductivity, metallic luster, and malleability....
All metallic solids exhibit high thermal and electrical conductivity, metallic luster, and malleability....
20.5K


