相关实验视频
Updated: Jan 20, 2026

04:39
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
2.4K
甲状腺功能测试异常和甲状腺自身免疫与早产的关联:系统性审查和分析
, T I M Korevaar1,2, Arash Derakhshan1,2
1Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.
JAMA
|August 21, 2019
概括
孕产妇临床下甲状腺功能低下,隔离性甲状腺氧化酶抗体阳性与早产风险增加有关. 这些发现有助于改进孕妇甲状腺查和治疗策略.
科学领域:
- 生殖内分泌学和孕产妇医学
- 孕期甲状腺疾病及其对产科结果的影响.
背景情况:
- 孕产妇甲状腺功能低下和甲状腺功能过高是早产的风险因素.
- 甲状腺功能较轻的异常,甲状腺自身免疫和早产之间的关联仍然存在争议.
- 了解这些关联对于优化产前护理和查方案至关重要.
研究的目的:
- 调查母亲甲状腺功能测试异常和甲状腺自身免疫是否是早产的风险因素.
- 分析亚临床甲状腺功能低下症,隔离性甲状腺功能低下症和甲状腺过氧化酶 (TPO) 抗体阳性与早产风险之间的联系.
主要方法:
- 对前性队列研究进行了系统审查和元分析.
- 分析了包括47045名孕妇在内的19个群体的数据.
- 甲状腺功能测试 (甲状腺激素[TSH]和自由甲状腺素[FT4]) 和TPO抗体测量与早产的结果进行了评估.
主要成果:
- 亚临床甲状腺功能低下症 (OR,1.29) 和孤立的甲状腺功能低下症 (OR,1.46) 与早产风险的增加显著相关.
- 孕产妇的TPO抗体阳性与早产风险较高相关 (OR,1. 33).
- 甲状腺激素度的增加与早产风险的增加持续相关.
结论:
- 在没有明显甲状腺疾病的孕妇中,亚临床甲状腺功能低下,孤立的甲状腺功能低下和TPO抗体阳性是导致早产的重要危险因素.
- 这些发现支持在怀孕期间考虑对这些疾病进行查.
- 结果为临床决策提供了有关查和levothyroxine治疗的潜在益处和危害的信息.
相关概念视频
Functions of Thyroid Hormones
5.0K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
5.0K
The Thyroid Gland
6.8K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
6.8K
Synthesis and Regulation of Thyroid Hormones
7.3K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
7.3K
Birth Control Methods
5.9K
Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although...
5.9K
Abnormal Proliferation
5.1K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.1K
Review and Preview
8.3K
In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
Percentiles are a type of fractile that partition data into...
8.3K

