来自微生物群的抗生素恢复了对抗万科菌的耐药性
Sohn G Kim1,2, Simone Becattini1, Thomas U Moody1,3
1Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Nature
|August 23, 2019
概括
一种肠道细菌的Blautia producta BPSCSK产生一种抗生素,可以降低抗万科菌的Enterococcus faecium (VRE) 殖民. 这种新生细菌及其抗生素有望作为抗VRE感染的益生菌.
科学领域:
- 微生物学
- 胃肠病学
- 传染性疾病
背景情况:
- 肠道的开始性细菌通常会阻止抗万科菌体 (VRE) 的殖民.
- 抗生素的使用可以破坏这种屏障,增加对VRE的易感性,
- 一个特定的共生联盟,包括Blautia producta BPSCSK,已经显示出逆转抗生素诱导的VRE敏感性的潜力.
研究的目的:
- 调查蓝产物BPSCSK抑制VRE殖民的机制.
- 在体外和体内比较BPSCSK及其分泌的抗生素的疗效.
- 探索产生抗生素的初生动物作为VRE耐药性的益生菌的潜力.
主要方法:
- 研究了BPSCSK的VRE抑制机制,确定了分泌的抗生素.
- 对比了BPSCSK和Lactococcus lactis对VRE生长和殖民的体外和体内影响.
- 在患者样本和无细菌小鼠中分析了兰地生物基因丰度与E. faecium密度之间的关联.
主要成果:
- BPSCSK通过分泌类似于nisin-A的抗生素来抑制VRE.
- 虽然BPSCSK和L. lactis都在体外抑制VRE,但只有BPSCSK在体内有效降低VRE密度.
- 与尼辛-A相比,BPSCSK抗生素对共生细菌的活性较低.
- 在患者和小鼠中,高的lantibiotic基因丰度与VRE密度降低相关.
结论:
- 产生抗生素的开始性细菌,如BPSCSK,可以有效地减少肠道中的VRE殖民.
- 由BPSCSK衍生而来的抗生素提供了一种针对性的方法,对有益的肠道菌群的影响较小.
- 这些发现支持开发产生抗生素的初生菌作为抗VRE感染的益生菌.
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