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相关概念视频

Conformity01:20

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Conformity is the change in a person’s behavior to go along with the group, even if that person does not agree with the group.
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Unlike ethane and propane that have only two major conformations, butane has more than two conformers. The staggered form of butane in which the bulky methyl groups on the two carbons are placed on opposite sides, that is, at a dihedral angle of 180°, is the lowest energy, most stable form — called the anti conformer. This conformation is stabilized due to the absence of steric repulsion between the largely spaced out methyl groups. The other two staggered conformations are...
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Atoms and molecules interact through bonds (or forces): intramolecular and intermolecular. The forces are electrostatic as they arise from interactions (attractive or repulsive) between charged species (permanent, partial, or temporary charges) and exist with varying strengths between ions, polar, nonpolar, and neutral molecules. The different types of intermolecular forces are ion–dipole, dipole–dipole, hydrogen bonds, and dispersion; among these, dipole–dipole, hydrogen...
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Adolf von Baeyer attempted to explain the instabilities of small and large cycloalkane rings using the concept of angle strain — the strain caused by the deviation of bond angles from the ideal 109.5° tetrahedral value for sp3  hybridized carbons. However, while cyclopropane and cyclobutane are strained, as expected from their highly compressed bond angles, cyclopentane is more strained than predicted, and cyclohexane is virtually strain-free. Hence, Baeyer’s theory that...
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Cyclohexane does not exist in a planar form due to the high angle and torsional strain it would experience in the planar structure. Instead, it adopts non-planar chair and boat conformations.
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在PIEZO1中引起的形状变化

Yi-Chih Lin1,2, Yusong R Guo3, Atsushi Miyagi1,2

  • 1Department of Anesthesiology, Weill Cornell Medicine, New York, NY, USA.

Nature
|August 23, 2019
PubMed
概括
此摘要是机器生成的。

机械敏感通道PIEZO1,一个将蛋白质转换为电信号的通道,可以反向地平整到细胞膜平面. 这种形状变化是PIEZO1对机械力反应的关键.

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科学领域:

  • 生物物理
  • 分子生物学
  • 细胞生物学

背景情况:

  • PIEZO1是一种机械敏感的离子通道,对于将机械力转化为细胞信号至关重要.
  • 之前的研究显示PIEZO1具有伸展臂的碗形三元体结构.

研究的目的:

  • 在不同的机械条件下研究PIEZO1的结构动态.
  • 阐明PIEZO1对膜张力和力量的反应机制.

主要方法:

  • 使用冷电子显微镜 (cryo-EM) 来观察不同大小的脂质囊泡中的PIEZO1结构.
  • 高速原子力显微镜 (HS-AFM) 分析了PIEZO1在支膜上的可变性.
  • 使用机械力来估计PIEZO1的弹常数.

主要成果:

  • 根据脂质囊泡的大小,PIEZO1具有不同程度的曲率.
  • 当PIEZO1受到强力的作用时,它可以在膜平面上进行可逆平整.
  • 使用力测量估计了PIEZO1的机械常数.

结论:

  • 证明了PIEZO1的形状变形能力,特别是平整成平面结构.
  • 这种形状的灵活性可能是通道门的侧面膜张力转换为自由能量变化的基础.
  • 这些发现为PIEZO1的机械传导提供了洞察力.