白血病抑制因子与DA细胞的骨髓生长因子人间白血素相同
J F Moreau1, D D Donaldson, F Bennett
1Genetics Institute Inc., Cambridge, Massachusetts 02140.
Nature
|December 15, 1988
概括
白血病抑制因子 (LIF) 是一种细胞因子,也作为某些白血病细胞的生长因子. 这一发现表明细胞类型决定了LIF是否促进生长或分化.
科学领域:
- 血液学 血液学 血液学
- 细胞生物学 细胞生物学
- 分子生物学分子生物学
背景情况:
- 已知白血病抑制因子 (LIF) 在髓状白血病细胞中诱导巨分化.
- 取决于互白素-3的DA-la细胞系是研究白血病细胞增殖的小鼠模型.
研究的目的:
- 为了识别和描述人类新型的造血成长因子.
- 调查DA细胞 (HILDA) 的人类互白素在白血病细胞增殖和分化中的作用.
主要方法:
- 一个编码为HILDA的cDNA克隆的分离.
- 测试HILDA对DA-la细胞系的增殖作用.
- 将HILDA与LIF等已知的细胞因子进行比较.
主要成果:
- 希尔达被确定为一种新型的人类造血生长因子.
- 发现HILDA与白血病抑制因子 (LIF) 相同.
- LIF支持DA-la白血病细胞系的扩散.
结论:
- 白血病抑制因子 (LIF) 表现出诱导分化和促进生长的活动.
- 目标细胞类型决定了LIF是否诱导生长或分化.
- 这突显了白血病细胞生物学中细胞因子功能的可塑性.
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