禁食对免疫细胞动力学和粘膜免疫反应的影响
Motoyoshi Nagai1, Ryotaro Noguchi1, Daisuke Takahashi2
1Division of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Science, Keio University, Tokyo 105-8512, Japan; Department of Gastroenterology, Research Center for Hepatitis and Immunology, Research Institute, National Center for Global Health and Medicine, Chiba 272-8516, Japan.
Cell
|August 24, 2019
概括
暂时禁食会显著降低肠道免疫细胞的数量, 这会影响免疫反应和肠道平衡,
科学领域:
- 免疫学
- 营养科学
- 胃肠病学
背景情况:
- 营养状况会影响免疫反应, 但根本的机制尚不清楚.
- 皮耶补丁 (PPs) 是肠道免疫的重要诱导部位.
研究的目的:
- 研究营养信号如何调节免疫细胞的动态和功能.
- 了解禁食和再食对肠道免疫平衡的影响.
主要方法:
- 一个模型系统中的临时禁食和再食协议.
- 在PP中分析淋巴细胞数量和细胞组成.
- 研究B细胞迁移模式和化学激素表达 (CXCL13).
- 对口服免疫,抗原特异性IgA诱导和口服耐受性的评估.
主要成果:
- 禁食使PP细胞的淋巴细胞数量减少了50%左右,并导致了胚胎中心和IgA+B细胞的显著亡.
- 在禁食期间,B细胞从PP细胞迁移到骨髓中,并在重新养时返回.
- 在重新养过程中,流体细胞上调了CXCL13的表达,将原始B细胞重新招募到PP中.
- 在口服免疫之前禁食会影响IgA诱导,口服耐受性,并加剧食物抗原诱导的腹.
结论:
- 营养信号关键调节肠道免疫细胞的动态和功能.
- 禁食会通过改变淋巴细胞的组成和功能来破坏肠道免疫平衡.
- 重新养恢复了淋巴细胞数量,但没有恢复原来的组成,影响了适应性免疫力.
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