在饮食限制期间,骨髓保护和优化免疫记忆
Nicholas Collins1, Seong-Ji Han1, Michel Enamorado1
1Metaorganism Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Cell
|August 24, 2019
概括
饮食限制导致记忆T细胞转移到骨髓, 这种免疫系统的适应在营养压力期间增强了对感染和瘤的保护.
科学领域:
- 免疫学
- 营养免疫学
- 细胞生物学
背景情况:
- 哺乳动物的免疫系统面临着不断变化的食物供应.
- 免疫系统适应短暂的营养压力是很难理解的.
研究的目的:
- 研究记忆T细胞如何适应饮食限制.
- 在营养压力期间了解骨髓在免疫记忆中的作用.
主要方法:
- 在饮食限制下研究了二次淋巴细胞和骨髓的记忆T细胞动态.
- 分析了葡萄糖皮质体,脂肪细胞和特定分子相互作用 (CXCR4-CXCL12,S1P-S1P1R) 在T细胞定位中的作用.
- 评估了骨髓T细胞积累对感染和瘤的保护的影响.
主要成果:
- 记忆T细胞在二次淋巴体器官减少,但在饮食限制期间在骨髓中积累.
- 骨髓T细胞进入了节能状态.
- 饮食限制诱导了骨髓重塑,包括T细胞归宿因子增加,红色形成和脂肪生成.
- 脂肪细胞和特定的分子相互作用促进了T细胞在骨髓中的积累.
- 骨髓内存T细胞提供了针对感染和瘤的增强保护.
结论:
- 免疫系统在营养挑战时将记忆T细胞重组为骨髓的"避风港".
- 这种空间重组维持了免疫记忆,并增强了饮食限制下的宿主防御.
- 葡萄皮质类药物在协调这种适应性免疫反应方面发挥着关键作用.
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