饮食摄入调节循环炎单细胞池
Stefan Jordan1, Navpreet Tung1, Maria Casanova-Acebes1
1Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA; The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA.
Cell
|August 24, 2019
概括
短期禁食会减少单细胞的活力和数量,改善炎症性疾病. 这种效应由肝脏能量传感器介导,影响免疫力,但不妨碍应急反应.
科学领域:
- 免疫学
- 代谢过程
- 营养科学
背景情况:
- 卡路里限制在治疗炎症和自身免疫性疾病方面是公认的.
- 减少热量摄入与炎症调节的确切机制尚不清楚.
研究的目的:
- 阐明短期禁食如何影响单细胞活动和数量.
- 确定这些变化的分子途径和饮食因素.
- 评估慢性炎症疾病和免疫反应的影响.
主要方法:
- 在临床前模型中研究了短期禁食对单细胞代谢和炎症活动的影响.
- 分析了饮食中的葡萄糖和蛋白质水平在调节外围单细胞数量的作用.
- 研究了5'-AMP激活蛋白激酶 (AMPK) 在肝细胞和多氧体增殖激活受体α (PPARα) 在单细胞调动中的作用.
主要成果:
- 短期禁食显著降低了循环单细胞数量及其炎症活性.
- 单细胞调节依赖于饮食中的葡萄糖和蛋白质.
- 肝细胞中的AMPK激活和PPARα介导的CCL2抑制减少了骨髓中的单细胞动员.
结论:
- 肝脏的热量摄入和能量传感器极大地影响了免疫力.
- 禁食可以通过调节单细胞活动和数量来改善慢性炎症.
- 在急性感染或组织修复过程中,这种调节不会损害单细胞的基本功能.
相关概念视频
Regulation of Food Intake
2.3K
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
2.3K
Regulation of Water Intake
2.6K
Osmolality refers to the number of solute particles per kilogram of solvent in a solution. Plasma osmolality specifically indicates the total number of solute particles per kilogram of water in blood plasma. This value reflects the body's hydration status and is tightly regulated through mechanisms controlling water intake and output. While water consumption is a conscious decision, the body has intrinsic regulatory systems to maintain fluid balance. Dehydration, a state of water deficit...
2.6K
Dietary Connections
61.5K
In biological systems, most metabolic pathways are interconnected. The cellular respiration processes that convert glucose to ATP—such as glycolysis, pyruvate oxidation, and the citric acid cycle—tie into those that break down other organic compounds. As a result, various foods—from apples to cheese to guacamole—end up as ATP. In addition to carbohydrates, food also contains proteins and lipids—such as cholesterol and fats. All of these organic compounds are used...
61.5K
Proteins: Dietary Sources and Requirements
1.6K
Consuming animal-based products offers high-quality proteins that contain optimal levels and combinations of essential amino acids, crucial for tissue repair and growth. Foods like eggs, milk, fish, and most meats are a source of complete proteins. Legumes and cereals are abundant in proteins; however, they typically lack a full range of essential amino acids. As a result, they are considered incomplete protein sources. Some plant sources like soybeans, quinoa, and amaranth do contain complete...
1.6K
Inflammatory Response
16.1K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
16.1K
Fetal Circulation
2.6K
Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
2.6K


