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Updated: Jan 20, 2026

Cell Surface Receptor Identification Using Genome-Scale CRISPR/Cas9 Genetic Screens
08:49

Cell Surface Receptor Identification Using Genome-Scale CRISPR/Cas9 Genetic Screens

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在CD8T细胞中使用基因尺度的CRISPR屏幕进行系统免疫疗法目标发现

Matthew B Dong1, Guangchuan Wang2, Ryan D Chow3

  • 1Department of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA; System Biology Institute, Integrated Science & Technology Center, Yale University, 850 W Campus Drive, West Haven, CT 06516, USA; Center for Cancer Systems Biology, Integrated Science & Technology Center, Yale University, 850 W Campus Drive, West Haven, CT 06516, USA; Yale MD-PhD Program, Yale University School of Medicine, New Haven, CT 06510, USA; Immunobiology Program, Yale University School of Medicine, New Haven, CT 06510, USA; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA.

Cell
|August 24, 2019
PubMed
概括

全基因组CRISPR查发现DHX37是癌症免疫治疗中CD8T细胞功能的关键调节剂. 抑制DHX37增强了抗瘤免疫力,提供了一个新的治疗点.

关键词:
CD8 T 细胞没有.T细胞效应器的功能收养转让乳腺癌免疫疗法在体内进行CRISPR检查lentiCRISPR 这是一个很好的方法.发现目标瘤透情况

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