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发育中的小鼠新皮质中的尖端原始体的时间可塑性

Polina Oberst^1,2, Sabine Fièvre¹, Natalia Baumann¹

¹Department of Basic Neurosciences, University of Geneva, Geneva, Switzerland.

|August 30, 2019

概括

新皮层前代细胞表现出令人惊的时间可塑性. 基前代可以恢复到早期的发育状态,与承诺的中间前代不同,在大脑发育过程中显示细胞命运的灵活性.

科学领域:

发展神经科学
细胞生物学
神经生物学

背景情况:

新皮质是从心室区域的尖端前代形成的.
从深层产生神经元到表面产生神经元.
个体祖先类型的时间可塑性和命运限制尚不清楚.

研究的目的:

在新皮层发育过程中研究尖端和中间祖先的时间可塑性.
为了确定祖先的命运是否意味着不可逆转的命运限制.

主要方法:

绝缘的顶端和中间的祖先.
通过向年轻胚胎进行异常移植来绘制神经元后代的命运.
分子,电生理和神经状态的分析.

主要成果:

形祖先表现出时间可塑性,当通过Wnt信号接触到年轻环境时,它们会恢复到早期状态.
中间的祖先是有承诺的, 缺乏逆向命运的可塑性.
在新皮层原始子类型中存在时间可塑性的多样性.

结论:

新皮层原生细胞的命运不是严格的线性;一些细胞可以逆转发育进展.
垂直的祖先是暂时的可塑性,而中间的祖先是命运的限制.
这种可塑性提供了对发育中的大脑细胞命运决定的动态调节的见解.

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