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细胞迁移和轴突引导在中枢神经系统和外周神经系统之间的边界

Tracey A C S Suter^1,2, Alexander Jaworski^3,2

¹Department of Neuroscience, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA.

Science (New York, N.Y.)

|August 31, 2019

概括

发展的神经系统建立了中枢神经系统 (CNS) 和外周神经系统 (PNS) 之间的界限. 这项研究探讨了细胞和轴突跨越中枢神经系统-脑神经系统边界的细胞和分子机制.

科学领域:

神经科学
发育生物学
细胞生物学

背景情况:

中枢神经系统 (CNS) 和外围神经系统 (PNS) 包含具有特殊功能的不同细胞类型.
一个有限的细胞跨越中枢神经系统和质神经系统的界限, 连接这两个主要的神经系统的分支.
在胚胎发育过程中通过细胞迁移和轴突引导建立了这种选择性连接性.

研究的目的:

提供控制细胞迁移和脊椎动物中枢神经系统-PNS边界的轴突指导的细胞和分子机制的概述.
要突出最近的进步,了解细胞体和轴突是如何跨越或尊重这个边界的.
介绍关于中枢神经系统 - 脑神经系统接口的发展和可塑性的开放问题.

主要方法:

对细胞和分子机制的现有文献进行审查.
对细胞迁移和轴突指导在中枢神经系统 - 脑神经系统边界的研究进行分析.
确定关键的分子线索和相关的细胞行为.

主要成果:

中枢神经系统 - 脑神经系统边界是一个关键的发育界面,细胞迁移和轴突指导受到严格调节.
特定的细胞和分子机制决定细胞和轴突是否跨越或尊重这一边界.
最近的进展揭示了影响边界相互作用的复杂信号通路和细胞内在因素.

结论:

了解中枢神经系统和脑神经系统的发展对于理解神经系统的组织至关重要.
需要进一步研究以充分阐明这一边界的可塑性和发育动态.
这种知识对再生医学和理解神经疾病有意义.

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