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Updated: Jan 20, 2026

Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides
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Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides

Published on: July 26, 2018

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高效多价糖体合成/[60]新兴病毒的富勒烯纳米球

Javier Ramos-Soriano1,2, José J Reina2, Beatriz M Illescas1

  • 1Departamento de Química Orgánica, Facultad de Química , Universidad Complutense , 28040 Madrid , Spain.

Journal of the American Chemical Society
|August 31, 2019
PubMed
概括

新的富勒烯基化合物通过向DC-SIGN受体有效地阻断寨卡病毒 (ZIKV) 和登革热病毒 (DENV). 这项研究为开发抗病毒疗法提供了一个有前途的策略.

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Here, we present protocols for the synthesis of disaccharide nucleosides by the regioselective O-glycosylation of ribonucleosides via a temporary protection of their 2',3'-diol moieties utilizing a cyclic boronic ester. This method applies to several unprotected nucleosides such as adenosine, guanosine, cytidine, uridine, 5-methyluridine, and 5-fluorouridine to give corresponding disaccharide...
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