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在多种乳腺癌模型中的转移中需要E-cadherin

Veena Padmanaban¹, Ilona Krol², Yasir Suhail³

¹Department of Cell Biology, Center for Cell Dynamics, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.

|September 6, 2019

概括

通过减少细胞存活和增殖,令人惊地阻碍了乳腺癌的转移. 这种蛋白质作为生存因子,在癌症扩散过程中防止反应性氧介导的亡.

科学领域:

癌症学
细胞生物学
癌症转移研究

背景情况:

转移是癌症相关死亡的主要原因.
之前假设E-cadherin损失导致癌症的侵袭和转移.
这种假设与许多侵袭性乳腺癌中的E-cadherin表达相冲突.

研究的目的:

研究E-cadherin在侵袭性导管癌的转移中的作用.
在转移性癌症中解决E-cadherin功能与其表达之间的差异.
阐明E-cadherin影响转移的分子机制.

主要方法:

使用光线和基底侵入性导管癌的小鼠和人类模型.
评估了转移中对E-cadherin的遗传需求.
分析了基因表达,细胞信号通路 (TGFβ,反应性氧物种,细胞亡) 和细胞表型.

主要成果:

发现E-cadherin可以促进侵袭性导管癌的转移.
失去E-cadherin会减少癌细胞的增殖,存活和转移.
与TGFβ和反应性氧物种信号相关的E- 阴性细胞显示出亡的增加.

结论:

在侵袭性导管癌中,E-cadherin作为生存因子,在转移期间保护细胞灭绝.
它限制了反应性氧物种介导的亡,促进了脱离,传播和播种.
针对E-cadherin介导的生存途径可以为转移性乳腺癌提供治疗策略.

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