通过序变化调整金纳米粒子单螺旋体的结构和手术特性
Soumitra Mokashi-Punekar, Tiffany R Walsh1, Nathaniel L Rosi
1Institute for Frontier Materials , Deakin University , Geelong , Victoria 3216 , Australia.
Journal of the American Chemical Society
|September 6, 2019
概括
研究人员编程了序列来控制金纳米粒子 (AuNP) 超结构的结构和手术活动. 中的简单分子变化精确调整纳米粒子大小和组合,影响传感应用的光学特性.
科学领域:
- 纳米技术和材料科学
- 生物分子工程
- 整形眼镜光谱
背景情况:
- 纳米粒子 (NP) 组件的光学特性取决于NP的大小,维度和排列.
- 化纳米材料,如金纳米粒子 (AuNP) 超结构,在传感,检测和光学方面具有潜力.
- 序列和排列决定了的功能,类似于NP排列如何影响NP组合特性.
研究的目的:
- 证明可以编程序来指导状螺旋 AuNP 超结构的结构和手术活动.
- 研究序的变化,特别是 metionin (M) 或 metionin sulfoxide (M-ox) 的位置,如何影响 AuNP 的大小和组装.
- 将纳米级结构变化与可观察到的手术信号强度差异相关联.
主要方法:
- 黄金结合联家族 (C18-(PEPAuM,2) 和C18-(PEPAuM-ox,2) 的合成,M/M-ox的位置不同.
- 使用计算建模来了解-AuNP相互作用及其对NP大小的影响.
- 描述了由此产生的AuNP超结构 (例如螺旋组件) 和它们的光学特性.
主要成果:
- 序列的变化极大地影响了与AuNP的相互作用,从而控制了NP的大小.
- C18-(PEPAuM,2) 形成了不规则的双螺旋结构与球形AuNP.
- C18-(PEPAuM-ox,2) 形成单螺旋组合与长方形或棒形AuNP,当M/M-ox在位置x=11时观察到更大的AuNP组成部分.
结论:
- 简单的原序列分子级调整可以极大地改变性AuNP超结构的结构和特性.
- 这项工作建立了一种通过基工程控制 AuNP 的面积比,尺寸和组装的方法.
- 这些发现突显了为特定应用设计具有可调整的手术活性的先进手术纳米材料的潜力.
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