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Updated: Jan 20, 2026

A Double Humanized BLT-mice Model Featuring a Stable Human-Like Gut Microbiome and Human Immune System
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抗生素驱动的肠道微生物乱改变了人类对疫苗的免疫力

Thomas Hagan1, Mario Cortese1, Nadine Rouphael2

  • 1Institute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Stanford, CA 94305, USA.

Cell
|September 7, 2019
PubMed
概括

在健康成年人中,抗生素没有影响流感抗体反应,但在具有较低预先存在标位的成年人中,抗生素会降低抗体反应. 微生物组通过炎症和代谢途径影响免疫力.

关键词:
抗体胆汁酸基因表达分析免疫学流感 的代谢学微生物群系统生物学系统疫苗学疫苗的使用

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