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相关概念视频

Prokaryotic Cells01:51

Prokaryotic Cells

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Prokaryotes are small unicellular organisms that include the domains—Archaea and Bacteria. Bacteria include many common organisms, such as Salmonella and E. coli, while the Archaea include extremophiles that live in harsh environments, such as volcanic springs.
Like eukaryotic cells, all prokaryotic cells are surrounded by a plasma membrane, have genetic material in the form of single, circular DNA, a cytoplasm that fills the interior of the cell, and ribosomes that synthesize proteins....
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Cytoskeletal Proteins in Bacteria01:29

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Bacterial cells were initially considered simple, randomly organized structures lacking a cytoskeleton. However, the discovery of cytoskeleton homologs in bacteria led to the change of this opinion. Bacterial cytoskeletal filaments regulate the cell shape, cell polarity, cell division, and partitioning of plasmids during cell division. It was later discovered that bacterial cytoskeletal proteins, mainly actin and tubulin homologs, are diverse compared to their eukaryotic counterparts. On the...
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Prokaryotic Cells01:28

Prokaryotic Cells

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Prokaryotes are small unicellular organisms that include the domains — Archaea and Bacteria. Bacteria include many common microorganisms, such as Salmonella and E. coli, while the Archaea include extremophiles that live in harsh environments, such as volcanic springs.
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Bacterial Flora of the Large Intestine01:29

Bacterial Flora of the Large Intestine

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The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
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Microbes in the Production of Fermented Foods01:27

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Lactic acid bacteria (LAB) and molds are instrumental in fermenting plant-based foods to enhance preservation and ensure year-round availability. These microbial processes convert plant carbohydrates into organic acids and other metabolites that inhibit spoilage organisms and contribute to the sensory qualities of the final product.In sauerkraut production, cabbage goes through a microbial succession that starts with cocci such as Leuconostoc mesenteroides. These microbes begin fermentation by...
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Microbiota of the Large Intestine01:27

Microbiota of the Large Intestine

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The large intestine hosts the most densely populated microbial ecosystem in the human body. This complex community primarily consists of anaerobic bacteria, with Bacillota (formerly Firmicutes) and Bacteroidota (formerly Bacteroidetes) as the predominant groups. The distribution of these microbes varies along different sections of the large intestine, influenced by local environmental factors such as oxygen availability and nutrient composition.The cecum, located at the beginning of the large...
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相关实验视频

Updated: May 2, 2026

Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device
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Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device

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菌体

Enno Schmidt1, Michael Kasperkiewicz2, Pascal Joly3

  • 1Department of Dermatology, University of Lübeck, Lübeck, Germany; Lübeck Institute for Experimental Dermatology, University of Lübeck, Lübeck, Germany.

Lancet (London, England)
|September 10, 2019
PubMed
概括
此摘要是机器生成的。

这是一种罕见的自身免疫性疾病,会引起水泡. 在中度至重度的病例中,Rituximab治疗可提供较高的缓解率,并减少皮质类固醇的副作用.

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科学领域:

  • 皮肤病学
  • 免疫学
  • 自身免疫性疾病

背景情况:

  • 这是一种严重的自身免疫性泡性疾病.
  • 致病性自身抗体向的是德斯莫格林 (Dsg) 1和Dsg3粘附蛋白.
  • 这种抗体结合会导致角质细胞分离 (角质溶解).

研究的目的:

  • 总结我们对菌病原和诊断的理解.
  • 突出目前的治疗策略,包括皮质类固醇和修复剂.
  • 评估利图西马布在管炎治疗中的疗效和益处.

主要方法:

  • 诊断包括直接免疫光显微镜的活检和血清ELISA抗Dsg抗体.
  • 主要治疗包括皮质类固醇.
  • 利图西马布 (抗CD20抗体) 用于中度至严重的病例.

主要成果:

  • 在90%的患者中,Rituximab在治疗结束后引起完全缓解.
  • 利图西马布可以快速降低皮质类固醇.
  • 这导致显著的皮质类固醇节约作用和减少不良事件.

结论:

  • 利图西马布是一种高效的治疗中度至重度的.
  • 它通过减少皮质类固醇可显著改善患者的治疗结果.
  • 利图西马布在治疗胞方面具有很大的好处,并且副作用较少.