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Updated: Jan 19, 2026

Creating Highly Specific Chemically Induced Protein Dimerization Systems by Stepwise Phage Selection of a Combinatorial Single-Domain Antibody Library
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打破对称性:为人工金属酶提供主体的单链二进制链条蛋白工程

Shuke Wu1, Yi Zhou1, Johannes G Rebelein1

  • 1Department of Chemistry , University of Basel , BPR 1096, Mattenstrasse 24a , CH-4058 Basel , Switzerland.

Journal of the American Chemical Society
|September 12, 2019
PubMed
概括

研究人员设计了一种新的单链二维性斯特雷普塔维丁 (scdSav) 支架,以克服人工金属酶 (ArM) 开发的局限性. 这种新的支架使准确的辅因子定位成为可能,大大提高了对具有挑战性的反应的催化活性和选择性.

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