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对质瘤细胞的质突触输入驱动大脑瘤的进展

Varun Venkataramani1,2,3, Dimitar Ivanov Tanev4,5,6, Christopher Strahle4

  • 1Department of Functional Neuroanatomy, Institute for Anatomy and Cell Biology, Heidelberg University, Heidelberg, Germany. varun.venkataramani@med.uni-heidelberg.de.

Nature
|September 20, 2019
PubMed
概括

科学家发现神经元与质瘤细胞之间有直接的突触连接. 这种神经质突触通信驱动质瘤的进展,但阻断AMPA受体可能提供新的治疗策略.

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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