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在剖腹产分娩中缩的微生物群和机会性病原体殖民
Yan Shao1, Samuel C Forster1,2,3, Evdokia Tsaliki4
1Host-Microbiota Interactions Laboratory, Wellcome Sanger Institute, Hinxton, UK.
Nature
|September 20, 2019
概括
剖腹产会破坏婴儿肠道微生物群的殖民,增加机会性病原体. 哺乳和阴道分娩有助于微生物健康发育, 这对婴儿的长期健康至关重要.
科学领域:
- 微生物学
- 新生儿健康
- 基因组学
背景情况:
- 婴儿的肠道微生物群在出生后迅速殖民, 受母亲和环境因素的影响.
- 早期肠道微生物群的乱与晚年疾病有关.
- 剖腹产对新生儿肠道微生物群的影响仍在争论中.
研究的目的:
- 对婴儿肠道微生物群早期发育的影响进行调查.
- 确定新生儿的特定微生物变化和相关风险.
- 了解医院环境在塑造新生儿肠道微生物群中的作用.
主要方法:
- 婴儿肠道微生物群 (1,679个样本) 和母体样本 (175对) 的纵向采样.
- 整个基因组的基因组测序和分析.
- 大规模培养和细菌菌株的全基因组测序.
主要成果:
- 剖腹产显著破坏了母体的细菌传播,并增加了机会性病原体 (菌,肠杆菌,克莱布西拉).
- 在接受母体抗生素预防的阴道分娩婴儿或未被母乳养的婴儿中观察到类似但较少的效应.
- 从新生儿期到婴儿期,分娩方式对肠道微生物群构成有重大影响.
结论:
- 传递方式是早期肠道微生物群的关键决定因素.
- 医院分娩,特别是剖腹产,与抗菌素耐药的机会性病原体的殖民有关.
- 早期肠道微生物组的组成对婴儿的健康和疾病风险有长期影响.
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