从舌头到大脑的酸味
Jin Zhang1, Hao Jin1, Wenyi Zhang1
1Howard Hughes Medical Institute, Columbia University, New York, NY 10032, USA; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA; Department of Neuroscience, Columbia University, New York, NY 10032, USA; Mortimer B. Zukerman Mind Brain and Behavior Institute, Columbia University, New York, NY 10027, USA.
Cell
|September 24, 2019
概括
皮素-1离子通道对于检测酸味至关重要, 这一发现揭示了一个专门用于酸味感觉的神经通路.
科学领域:
- 神经科学
- 感官生物学
- 分子生物学
背景情况:
- 酸味感觉是防止摄入有害物质的重要保护机制,
- 在口腔中的酸刺激激活了味觉和体感受体,导致厌恶反应.
研究的目的:
- 研究酸味检测的分子机制.
- 找出特定的离子通道和神经通道参与酸味感知.
主要方法:
- 使用淘汰赛小鼠模型评估Otopetrin-1 (Otop1) 在味觉受体细胞 (TRC) 中的作用.
- 基因工程小鼠在甜味TRC中表达Otop1,以观察功能变化.
- 对调解基本味觉特性的味觉神经元进行了基因鉴定.
主要成果:
- 在酸感应TRC中,Otop1淘汰小鼠完全失去了酸性反应.
- 在甜的TRC中表达Otop1赋予了这些细胞酸感应能力.
- 确定了从舌头到大脑的酸味神经通路 (标记线).
结论:
- 奥托佩特林-1是酸味感觉的重要质子选择通道.
- 酸味的感知依赖于专门的神经回路,
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