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Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
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UNC93B1使用合成蛋白来抑制TLR7信号并防止自身免疫

Olivia Majer1, Bo Liu2, Lieselotte S M Kreuk1

  • 1Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.

Nature
|September 24, 2019
PubMed
概括

托尔类受体 (TLR) 护卫体UNC93B1特别限制TLR7的信号传递,防止TLR7依赖的自身免疫. 这种机制涉及UNC93B1与syntenin-1的结合,调节TLR7对外体的分类并设置其激活值.

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